Factors associated with anxiety and depression in perimenopausal women with abnormal uterine bleeding: A retrospective cohort study

Table 8 Interaction effects between endocrine markers and lifestyle and clinical factors on anxiety and depression in perimenopausal women with abnormal uterine bleeding (n = 1234)

Interaction Term	Multivariate OR (95% CI)	P-value
Estradiol (pg/mL) × Smoking History	1.08 (1.02–1.14)	0.006**
FSH (mIU/mL) × Exercise Regularly (≥ 3 times/week)	0.92 (0.88–0.97)	< 0.001***
Cortisol (µg/dL) × Smoking History	1.12 (1.05–1.18)	< 0.001***
LH (mIU/mL) × Exercise Regularly (≥ 3 times/week)	0.95 (0.91–0.99)	0.015*
TSH (mIU/L) × Exercise Regularly (≥ 3 times/week)	0.89 (0.82–0.97)	0.005**
Cortisol (µg/dL) × Psychiatric History	1.14 (1.06–1.23)	< 0.001***

Note: OR = Odds Ratio; CI = Confidence Interval. P-values were calculated using multivariate logistic regression models that included interaction terms between endocrine markers and lifestyle factors (smoking, exercise) and clinical history (psychiatric history). *Significance levels: *P < 0.05, **P < 0.01, ***P < 0.001

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