Table 3 Comparison of indicators in different MMSE score groups

Age [y, (P25, P75)]

62(56,69)

73(64,78)^a

68(59,77)^a

69.5(59,76)^a

Sex(M/F)

32/30

19/19

21/10

27/15

Education level ≥ 12y (n, %)

51(82.26)

34(91.89)

26(83.87)

33(78.57)

Hypertension (n, %)

39(62.9)

25(67.57)

20(64.52)

30(71.43)

History of Coronary heart disease

(n, %)

24(38.71)

15(40.54)

12(38.71)

15(35.71)

History of Diabetes mellitus

(n, %)

4(6.45)

12(32.43)^a

6(19.35)

12(28.57)^a

History of Smoking

(n, %)

29(46.77)

17(45.95)

16(51.61)

18(42.86)

History of Drinking

(n, %)

22(35.48)

15(40.54)

16(51.61)

17(40.48)

History of Stroke or cerebral infarction

(n, %)

22(35.48)

20(54.05)

20(64.52)^a

25(59.52)^a

History of Hypohepatia

(n, %)

6(9.68)

4(10.81)

0(0)

2(4.76)

History of Renal dysfunction

(n, %)

4(6.45)

5(13.51)

2(6.45)

4(9.52)

History of Thyroid dysfunction

(n, %)

4(6.45)

3(8.11)

2(6.45)

3(7.14)

Family history of dementia

(n, %)

8(12.9)

2(5.41)

3(9.68)

6(14.29)

Other family history

(n, %)

38(61.29)

11(29.73)^a

18(58.06)^b

16(38.1)^a

Hight [ cm, (P25, P75)]

164(160–170)

164(159–170)

167(162–170)

165(160–170)

Weight(kg)

67.82 ± 11.86

63.32 ± 13.76

66.47 ± 7.77

67.88 ± 10.91

SBP [mmHg, (P25, P75)]

140(130,149)

140(125,150)

148(135,160)

143(130,152)

DBP [mmHg, (P25, P75)]

80(79,90)

86(80,90)

90(80,93)

82.5(80,91)

Glu(mmol/L)

5.67(5.03–6.78)

5.3(5.01–6.43)

5.6(4.93–6.79)

5.73(5.2–7.05)

TG(mmol/L)

1.68(0.98–2.52)

1.41(1.05–2.05)

1.18(1-1.59)

1.38(0.98–1.97)

T-CH(mmol/L)

4.49(3.92–5.23)

4.89(3.79–5.38)

4.51(3.87–5.16)

4.43(4.11–5.18)

LDL-C(mmol/L)

2.88(2.3–3.3)

2.94(2.46–3.44)

3.07(2.21–3.78)

2.84(2.47–3.28)

HDL-C(mmol/L)

1.14(0.94–1.39)

1.09(0.92–1.29)

1.09(0.89–1.36)

1.21(1.03–1.46)

BUN(mmol/L)

5.51(4.27–6.59)

5.87(5.03–7.11)

5.81(5.01–6.91)

6.03(4.79–7.15)

Cr(umol/L)

78.05(64-89.1)

82.6(70.5-101.7)

81.6(69.5–96.2)

80.7(67.9–86.6)

ALT(U/L)

18(13–26)

12(8–18)^a

16(12–22)^b

19.5(15–28)^b

AST(U/L)

17(13–23)

13(12–17)^a

15(13–22)

18.5(15–23)^b

WBC (10⁹/L)

7.1(5.9–8.1)

7(6.2–9.2)

6.9(5.2–8.2)

7.25(6-8.1)

CRP(mg/L)

1.57(0.94–3.65)

2.68(1.43–6.07)^a

1.56(0.67–3.27)^b

2.03(0.81–6.35)

ADMA concentration(umol/L)

50.15 ± 12.81

54.74 ± 13.18

52.85 ± 13.4

55.36 ± 11.68

1.7428

0.1602

GFR(ml/min)

58.79(36.2-94.33)

71.59(38.52–93.32)

66.6(38.66–98.99)

63.2(34.09–89.7)

Ccr(ml/min)

76.8(61.43–95.78)

58.11(39.54–76.48)^a

70.21(51.79–88.35)

75.13(61.12–85.78)^b

MMSE score (P25, P75)

27(26,28)

17(15,19)^a

22(21,23)^ab

24(24,25)^abc

MoCA score

21.18 ± 3.7

10.38 ± 3.79^a

15.35 ± 3.92^ab

18.33 ± 3.94^abc

Adjustive MMSE

(Based on education) (P25, P75)

28(27,29)

18(16,20)^a

23(22,24)^ab

25(25,26)^abc

Adjustive MoCA (Based on education)

22 ± 3.54

11.3 ± 3.74^a

16.19 ± 3.67^ab

19.12 ± 3.74^abc

69.9711

< 0.0001^*