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Table 3 Interaction between SGA and COMT polymorphism rs5993883 on cognition in bipolar patients (using GG genotype as a reference)

From: Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder

Cognitive parameter

Verbal attentiona (r 2 = 0.25)

Verbal delayed recalla (r 2 = 0.21)

Cognitive controlb (r 2 = 0.15)

 

beta

p value

beta

p value

beta

p value

SGA

−10.03

0.0019

−3.03

0.0022

−0.08

<0.0001

COMT genotype

−4.65

0.013

−1.43

0.013

−0.007

0.54

Main Interaction

7.95

0.028

2.38

0.026

0.083

0.0005

  1. This model was adjusted for age, education, gender, diagnosis, prior hospitalizations, benzodiazepines and antidepressant use
  2. aAge, education and gender were also significant parameters in this model
  3. bAge was also a significant parameter in this model
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BMC Psychology

ISSN: 2050-7283

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